A prodrug of epigallocatechin-3-gallate alleviates high glucose-induced pro-angiogenic factor production by inhibiting the ROS/TXNIP/NLRP3 inflammasome axis in retinal Müller cells
Jingxia Du, Ying Wang, Yuanyuan Tu, Yang Guo, Xiaodong Sun, Xun Xu, Xiaojuan Liu, Li Wang, Xiao Qin, Manhui Zhu, E Song
Topics & Concepts
TXNIPInflammasomeThioredoxin-Interacting ProteinVascular endothelial growth factorCell biologyCancer researchChemistryHepatocyte growth factorAngiogenesisDownregulation and upregulationAzoxymethaneVascular endothelial growth factor APharmacologyBiologyOxidative stressThioredoxinBiochemistryReceptorCarcinogenesisGeneVEGF receptorsRetinal Diseases and TreatmentsInflammasome and immune disordersAdvanced Glycation End Products research