mTORC1 hyperactivation in lymphangioleiomyomatosis leads to<i>ACE2</i>upregulation in type II pneumocytes: implications for COVID-19
Yan Tang, David J. Kwiatkowski, Elizabeth P. Henske
Abstract
<b>Increased pneumocyte expression of the SARS-CoV-2 entry receptor ACE2 in lymphangioleiomyomatosis (LAM) is associated with upregulation of interferon pathways in natural killer cells as well as increased IL6 expression in LAM-associated fibroblasts</b>https://bit.ly/34ChSsg
Topics & Concepts
Downregulation and upregulationLymphangioleiomyomatosismTORC1Cancer researchReceptorBiologyChemistryCell biologyLungGeneMedicineSignal transductionPI3K/AKT/mTOR pathwayInternal medicineGeneticsTuberous Sclerosis Complex ResearchHistiocytic Disorders and TreatmentsRenal and related cancers