Biochemical Properties and Roles of DprA Protein in Bacterial Natural Transformation, Virulence, and Pilin Variation
Dhirendra Kumar Sharma, Hari S. Misra, Subhash C. Bihani, Yogendra S. Rajpurohit
Abstract
gene occurs in the genomes of all known bacteria, irrespective of their natural transformation status. The DprA protein has been characterized by its molecular, cellular, biochemical, and biophysical properties in several bacteria. This review summarizes different aspects of DprA biology, collectively describing its biochemical properties, molecular interaction with DNA, and function interaction with bacterial RecA during natural transformation. Furthermore, the roles of DprA in natural transformation, bacterial virulence, and pilin variation are discussed.
Topics & Concepts
BiologyTransformation (genetics)PilinPlasmidDNAGeneticsPilusVirulenceBacteriaGeneComputational biologyMicrobiologyBacterial Genetics and BiotechnologyAntibiotic Resistance in BacteriaEnterobacteriaceae and Cronobacter Research