Functional and Oncological Outcomes of Female Pelvic Organ–preserving Robot-assisted Radical Cystectomy
Étienne Lavallée, Zach Dovey, Prachee Pathak, Linda Dey, Lotta Renström Koskela, Arad Hosseini, Nikhil Waingankar, Reza Mehrazin, John P. Sfakianos, Abolfazl Hosseini, Peter Wiklund
Abstract
BACKGROUND: For females undergoing cystectomy and urinary diversion, decreases in sexual and urinary functions can have a significant impact on quality of life. Pelvic organ-preserving (POP) radical cystectomy (RC) has been proposed as an approach to improve postoperative functional outcomes. OBJECTIVE: To evaluate postoperative functional outcomes of a robotic approach for female POP RC with intracorporeal urinary diversion. DESIGN SETTING AND PARTICIPANTS: This was a multicenter retrospective study evaluating sexual, urinary, and oncological outcomes for sexually active females undergoing POP robot-assisted RC for ≤T2 bladder cancer. Exclusion criteria included multifocal, trigonal, or locally advanced tumors. SURGICAL PROCEDURE: We describe a step-by-step technique for POP robot-assisted RC with intracorporeal urinary diversion. MEASUREMENTS: The primary outcome of the study was evaluation of sexual and urinary functions following surgery. Oncological outcomes were evaluated as a secondary endpoint. RESULTS AND LIMITATIONS: Our study included 23 females who underwent POP robot-assisted RC between 2008 and 2020 with intracorporeal neobladder (87%) or ileal conduit (13%) reconstruction. The median follow-up was 20 mo. A postoperative sexual function questionnaire was completed by 15 patients (65%). Of those, 13 (87%) resumed sexual activity at a median of 6 mo after surgery. Of the patients with a neobladder, 14 (70%) achieved daytime continence and 16 (80%) achieved nighttime continence. Cancer-specific and overall survival were both 91%. The results are limited by their retrospective nature. CONCLUSIONS: POP robot-assisted RC with orthotopic neobladder allows a majority of female patients to return to sexual activity after surgery. This approach should be considered for selected sexually active women. PATIENT SUMMARY: We evaluated 23 women with bladder cancer who underwent surgical removal of the bladder with preservation of their reproductive organs. Following this surgery, a majority of patients resumed sexual activity. For selected patients, this technique can be performed without compromising cancer control.