A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages
Xiaofei Shen, Hongqing Chen, Hai Zhang, Liuling Luo, Tian Wen, Lu Liu, Qiongying Hu, Lun Wang
Topics & Concepts
NF-κBLipopolysaccharideChemistrySesquiterpene lactoneIκBαPharmacologyInflammationIκB kinaseTumor necrosis factor alphaKEAP1Signal transductionIn vivoBiochemistryBiologyImmunologySesquiterpeneTranscription factorStereochemistryBiotechnologyGeneNatural product bioactivities and synthesisPhytochemistry and Biological ActivitiesPhytochemistry and Bioactive Compounds