Elucidating cuproptosis-linked redox dynamics in Wilson's disease <i>via</i> a reversible ratiometric fluorescence strategy
Shunping Zang, Qingguo He, Yuyang Zeng, Yuyang Huang, Benhua Wang, Qing Liu, Xiangzhi Song
Abstract
The redox dynamics in cuproptosis and Wilson's disease (WD) were revealed using a reversible and ratiometric HOCl/GSH fluorescent probe, WD-Redox. It visualizes redox imbalances caused by excessive copper accumulation and monitors therapeutic effects of D-penicillamine. The probe's utility in studying oxidative stress in copper metabolism disorders and evaluating drug efficacy has been demonstrated.
Topics & Concepts
RedoxFluorescenceChemistryDynamics (music)BiophysicsPhotochemistryNanotechnologyCombinatorial chemistryMaterials scienceBiologyInorganic chemistryPhysicsQuantum mechanicsAcousticsTrace Elements in HealthHeavy Metal Exposure and ToxicityMetal complexes synthesis and properties