Inhibition of Mitochondrial Succinate Dehydrogenase with Dimethyl Malonate Promotes M2 Macrophage Polarization by Enhancing STAT6 Activation
Chaowen He, Pengfei Chen, Ning Li, Xiuping Huang, Huimin Sun, Yuanyuan Wang, Yanli Zhao, Changchun Zeng, Dongsheng Huang, Hanchao Gao, Mengtao Cao
Topics & Concepts
STAT6Macrophage polarizationSuccinate dehydrogenaseCell biologyChemokineM2 MacrophageMitochondrionMacrophageReactive oxygen speciesMitochondrial ROSNADPH oxidaseChemistryBiologyInflammationCancer researchBiochemistryCytokineImmunologyInterleukin 4In vitroImmune cells in cancerTryptophan and brain disordersImmune Cell Function and Interaction