Zinc(II) Complex with Pyrazolone-Based Hydrazones is Strongly Effective against <i>Trypanosoma brucei</i> Which Causes African Sleeping Sickness
F. Marchetti, Alessia Tombesi, Corrado Di Nicola, Riccardo Pettinari, Federico Verdicchio, Alessandra Crispini, Francesca Scarpelli, Cecilia Baldassarri, Elisa Marangoni, Anders Hofer, Agustı́n Galindo, Riccardo Petrelli
Abstract
and its Zn(II) complex showed that the drugs had a strong impact on the CTP pools, making it likely that CTP synthetase is the targeted enzyme.
Topics & Concepts
ChemistryTrypanosoma bruceiPyrazoloneZincLigand (biochemistry)StereochemistryOctahedronMoleculeMedicinal chemistryCrystallographyCrystal structureReceptorOrganic chemistryBiochemistryGeneTrypanosoma species research and implicationsSynthesis and Biological EvaluationResearch on Leishmaniasis Studies