Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis
Wei Zhen Yeh, Melissa Gresle, Vilija Jokubaitis, Jim Stankovich, Anneke van der Walt, Helmut Butzkueven
Abstract
Initially recognised as an important factor for bone health, vitamin D is now known to have a range of effects on the immune system. Vitamin D deficiency is associated with an increased risk of multiple sclerosis (MS), a chronic immune-mediated demyelinating disease of the CNS. In this review, we explore the links between vitamin D deficiency, MS risk, and disease activity. We also discuss the known immune effects of vitamin D supplementation and the relevance of these observations to the immunopathology of MS. Finally, we review the existing evidence for vitamin D supplementation as an MS therapy, highlighting several recent clinical studies and trials.