Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell Immunity
Eunok Lee, Kerrie J. Sandgren, Gabriel Duette, Vicki V Stylianou, Rajiv Khanna, John‐Sebastian Eden, Emily Blyth, David Gottlieb, Anthony L. Cunningham, Sarah Palmer
Abstract
The development of specific and validated immunologic tools is critical for understanding the level and duration of the cellular response induced by SARS-CoV-2 infection and/or vaccines against this novel coronavirus disease. To contribute to this effort, we employed an immunoinformatics analysis pipeline to define 57 SARS-CoV-2 immunogenic peptides within topologically important regions of the nucleocapsid (NC) and spike (S) proteins that will be effective for detecting cellular immune responses in 80 to 100% of the global population.
Topics & Concepts
BiologyEpitopeVirologyCoronavirusImmune systemSpike (software development)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PopulationImmunitySpike ProteinComputational biologyImmunologyAntibodyCoronavirus disease 2019 (COVID-19)DiseaseInfectious disease (medical specialty)DemographyEconomicsSociologyPathologyMedicineManagementvaccines and immunoinformatics approachesSARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune Responses