Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues
Guoliang Zhu, Wupeng Yan, Xinye Wang, Ronghai Cheng, Nathchar Naowarojna, Kun Wang, Jun Wang, Heng Song, Yuyang Wang, Hairong Liu, Xuekui Xia, Catherine E. Costello, Xueting Liu, Lixin Zhang, Pinghua Liu
Abstract
) was used as a second substrate analogue to study the alcohol dehydrogenation reaction to examine the involvement of the Y224 radical or Y68 radical in FtmOx1-catalysis, and again, the results from the verruculogen reaction are more consistent with the COX-like model.
Topics & Concepts
DehydrogenationChemistryCatalysisHydroxylationAlkylationSubstrate (aquarium)AlcoholTernary complexReaction mechanismStereochemistryMedicinal chemistryOrganic chemistryEnzymeBiologyEcologyMetal-Catalyzed Oxygenation MechanismsVanadium and Halogenation ChemistryHeme Oxygenase-1 and Carbon Monoxide