The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition
Hui Chen, Bin Wang, Peng Li, Hong Yan, Gang Li, Haihong Huang, Yu Lu
Topics & Concepts
AntimycobacterialSulfonamideMycobacterium tuberculosisChemistryMoietyPyrazoleCytotoxicityPharmacologyTuberculosisCombinatorial chemistryStereochemistryIn vitroBiochemistryMedicinePathologyPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Catalytic ReactionsEnzyme function and inhibition