Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells
Mohamed S. Nafie, Atef M. Amer, Anaiat K. Mohamed, Eman S. Tantawy
Topics & Concepts
MCF-7ChemistryApoptosisKinaseCytotoxic T cellCancer cellCell cycle checkpointCell cycleIC50In vitroFlow cytometryCancer researchCancerBiochemistryMolecular biologyBiologyHuman breastGeneticsCancer Mechanisms and TherapySynthesis and biological activitySynthesis and bioactivity of alkaloids