The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway
Menglong Gao, Lishun Dong, Yulong Yang, Jinjin Yan, Yuning Liang, Xiaolin Ma, Min Zhou, Hongfei Wu, Yarong Liu, Min Dai
Topics & Concepts
Foam cellPaeonolLipid metabolismGene knockdownGPX4ChemistryHMGB1Cell biologyMacrophageContext (archaeology)ApoptosisPharmacologyIn vitroBiochemistryBiologyOxidative stressMedicineSuperoxide dismutasePathologyAlternative medicineGlutathione peroxidaseReceptorPaleontologyFerroptosis and cancer prognosisCancer-related molecular mechanisms researchCircular RNAs in diseases