Microcirculatory model predicts blood flow and autoregulation range in the human retina: in vivo investigation with laser speckle flowgraphy
Konstantinos Pappelis, Lars Choritz, Nomdo M. Jansonius
Abstract
We describe and test a new approach to quantify retinal blood flow, based on standard clinical examinations and imaging techniques, linked together with a physiological model. We use these findings to generate individualized estimates of the autoregulation range. We provide evidence that healthy subjects are closer to the lower autoregulation limit than thought before. This suggests that some retinas are less prepared to withstand hypoperfusion, even after small intraocular pressure rises or blood pressure drops.
Topics & Concepts
AutoregulationSpeckle patternBlood flowPerfusionLaser Doppler velocimetryRetinaBlood pressureIn vivoHemodynamicsMedicineRetinalOphthalmologyBiomedical engineeringCardiologyInternal medicineNeuroscienceOpticsBiologyPhysicsBiotechnologyGlaucoma and retinal disordersRetinal Imaging and AnalysisRetinal Diseases and Treatments