An electronic proton-trapping ion pump for selective drug delivery
Xenofon Strakosas, Maria Seitanidou, Klas Tybrandt, Magnus Berggren, Daniel T. Simon
Abstract
), which exhibit higher ionic mobility than GABA, are also delivered and may potentially cause side effects due to large local changes in pH. To reduce the proton transfer, we introduced proton traps along the selective channel membrane. The traps are based on palladium (Pd) electrodes, which selectively absorb protons into their structure. The proton-trapping Pd-OEIP improves the overall performance of the current state-of-the-art OEIP, namely, its temporal resolution, efficiency, selectivity, and dosage precision.
Topics & Concepts
TrappingProtonDrug deliveryDrugChemistryNeurotransmitterIonBiophysicsNanotechnologyMaterials sciencePharmacologyBiochemistryBiologyPhysicsReceptorQuantum mechanicsEcologyOrganic chemistryAnalytical Chemistry and SensorsConducting polymers and applicationsElectrochemical Analysis and Applications