The recent advances in the mathematical modelling of human pluripotent stem cells
Laura E. Wadkin, Sirio Orozco-Fuentes, Irina Neganova, Majlinda Lako, Anvar Shukurov, N. G. Parker
Abstract
Human pluripotent stem cells hold great promise for developments in regenerative medicine and drug design. The mathematical modelling of stem cells and their properties is necessary to understand and quantify key behaviours and develop non-invasive prognostic modelling tools to assist in the optimisation of laboratory experiments. Here, the recent advances in the mathematical modelling of hPSCs are discussed, including cell kinematics, cell proliferation and colony formation, and pluripotency and differentiation.
Topics & Concepts
Induced pluripotent stem cellRegenerative medicineStem cellHuman Induced Pluripotent Stem CellsComputer scienceBiologyComputational biologyEmbryonic stem cellCell biologyGeneBiochemistryPluripotent Stem Cells Research3D Printing in Biomedical ResearchGene Regulatory Network Analysis