Photophysical Properties and DNA Binding of Two Intercalating Osmium Polypyridyl Complexes Showing Light-Switch Effects
Mark Stitch, Rayhaan Z. Boota, Alannah S. Chalkley, Tony D. Keene, Jeremy C. Simpson, Paul A. Scattergood, Paul I. P. Elliott, Susan J. Quinn
Abstract
to the presence of AT DNA, where a 6-fold enhancement of luminescence is observed and reflects the nature of the binding for the enantiomer and the protection from solution. Thermal denaturation studies show that both complexes are found to stabilize natural DNA. Finally, cellular studies show that the complexes are internalized by cultured mammalian cells and localize in the nucleus.
Topics & Concepts
ChemistryPhenazineOsmiumIntercalation (chemistry)EnantiomerLuminescenceLigand (biochemistry)DNAQuantum yieldPhotochemistryStereochemistryCrystallographyFluorescenceInorganic chemistryRutheniumOrganic chemistryReceptorCatalysisPhysicsQuantum mechanicsOptoelectronicsBiochemistryMetal complexes synthesis and propertiesDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniques