Effector memory CD4<sup>+</sup> T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells.
Margaret M. McDaniel, Amanpreet Singh Chawla, Aakanksha Jain, Hannah E. Meibers, Irene Saha, Yajing Gao, Viral G. Jain, Krishna M. Roskin, Sing Sing Way, Chandrashekhar Pasare
Abstract
instruction of the innate immune system is a primary driver of associated immunopathology. Thus, we have identified a previously unknown trigger of cytokine storm and autoimmune pathology that is amenable to therapeutic interventions.
Topics & Concepts
Innate immune systemImmunologyInflammationBiologyProinflammatory cytokineCytokineMyeloidCytokine stormInnate lymphoid cellTumor necrosis factor alphaImmune systemToll-like receptorEffectorMedicineDiseasePathologyCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)T-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses