Long noncoding RNA PART1 restrains aggressive gastric cancer through the epigenetic silencing of PDGFB via the PLZF-mediated recruitment of EZH2
Haibo Han, S. Wang, Jialin Meng, Guangmei Lyu, G. Ding, Yanting Hu, L. Wang, Lili Wu, W. Yang, Yao Lv, Shuqin Jia, Lianhai Zhang, Jiafu Ji
Topics & Concepts
BiologyCancer researchCarcinogenesisPDGFBCancerLong non-coding RNAProstate cancerMetastasisChromatin immunoprecipitationOncogenePI3K/AKT/mTOR pathwayGene silencingPTENDownregulation and upregulationSignal transductionCell biologyPromoterGene expressionPlatelet-derived growth factor receptorCell cycleGeneticsGrowth factorReceptorGeneCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing