The Hsp40 Mas5 Connects Protein Quality Control and the General Stress Response through the Thermo-sensitive Pyp1
Susanna Boronat, Luís Marte, Montserrat Rojo de la Vega, Sarela García‐Santamarina, Margarita Cabrera, José Ayté, Elena Hidalgo
Abstract
Pyp1 is sent to proteasomal degradation even in the absence of stress. We propose that Pyp1 is a thermo-sensitive phosphatase, which during heat stress coalescences into PACs in a Mas5-dependent manner, to promote full activation of the anti-stress Sty1-Atf1 cascade.
Topics & Concepts
PhosphataseCell biologyTranscription factorProtein tyrosine phosphataseHeat shock proteinHsp90YeastChemistryHeat shockBiologyBiochemistrySignal transductionGenePhosphorylationHeat shock proteins researchGenetics, Aging, and Longevity in Model OrganismsEndoplasmic Reticulum Stress and Disease