<i>In vitro</i> antimicrobial, physicochemical, pharmacokinetics and molecular docking studies of benzoyl uridine esters against SARS-CoV-2 main protease
Mohammed Mahbubul Matin, Monir Uzzaman, S Chowdhury, M. M. H. Bhuiyan
Abstract
(1R51). Significant binding affinities were observed against SARS-CoV-2 main protease (7BQY) considering hydroxychloroquine (HCQ) as standard. ADMET predictions were investigated to evaluate their absorption, metabolism and toxic properties. Most of the uridine esters showed better results than that of the HCQ. Overall, the present study might be useful for the development of uridine-based novel MDR antimicrobial and COVID-19 drugs.
Topics & Concepts
AntimicrobialChemistryAspergillus flavusUridineDocking (animal)BiochemistryIn vitroAntibacterial activityMicrobiologyPharmacologyBacteriaBiologyRNAOrganic chemistryFood scienceMedicineGeneticsGeneNursingSynthesis and biological activityComputational Drug Discovery MethodsPhenothiazines and Benzothiazines Synthesis and Activities