Effects of elevated positive end-expiratory pressure on diaphragmatic blood flow and vascular resistance during mechanical ventilation
Andrew G. Horn, Dryden R. Baumfalk, Kiana M. Schulze, Olivia Kunkel, Trenton D. Colburn, Ramona E. Weber, Christian S. Bruells, Timothy I. Musch, David C. Poole, Bradley J. Behnke
Abstract
This is the first study, to our knowledge, demonstrating that mechanical ventilation, with low and high positive-end expiratory pressure (PEEP), increases vascular resistance and reduces total and regional diaphragm perfusion. The rapid reduction in diaphragm perfusion and increased vascular resistance may initiate a cascade of events that predispose the diaphragm to vascular and thus contractile dysfunction with prolonged mechanical ventilation.
Topics & Concepts
Mechanical ventilationMedicineVascular resistancePositive end-expiratory pressureDiaphragm (acoustics)CardiologyPerfusionAnesthesiaVentilation (architecture)Diaphragmatic breathingInternal medicineHemodynamicsPathologyAlternative medicinePhysicsAcousticsMechanical engineeringLoudspeakerEngineeringRespiratory Support and MechanismsCardiac Arrest and ResuscitationThermal Regulation in Medicine