P<sup>III</sup>-Mediated intramolecular cyclopropanation and metal-free synthesis of cyclopropane-fused heterocycles
Jiayong Zhang, Jiahang Hao, Zhiqiang Huang, Jie Han, Zhengjie He
Abstract
A P(NMe2)3-mediated reductive intramolecular cyclopropanation is developed for the first time, which provides facile access to a wide variety of cyclopropane-fused heterocycles including chromanes, tetrahydroquinolines, lactones, and lactams. Catalytic hydrogenative ring-expansion of the cyclopropane-fused heterocycles is also elaborated, leading to various structurally important medium-sized heterocycles.
Topics & Concepts
CyclopropanationCyclopropaneIntramolecular forceChemistryMetalStereochemistryOrganic chemistryCatalysisRing (chemistry)Cyclopropane Reaction MechanismsSynthetic Organic Chemistry MethodsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry