Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a)
Michael J. Koren, Patrick M. Moriarty, Seth J. Baum, Joel Neutel, Martha Hernandez‐Illas, Howard Weintraub, Mónica Florio, Helina Kassahun, Stacey Melquist, Tracy Varrieur, Saptarsi M. Haldar, Winnie Sohn, Huei Wang, Mary Elliott‐Davey, Brooke M. Rock, Tao Pei, Oliver Homann, Jennifer Hellawell, Gerald F. Watts
Topics & Concepts
Small interfering RNAMedicineTolerabilityLipoprotein(a)LipoproteinPharmacologyPharmacokineticsCoronary artery diseaseClinical trialInternal medicineRNAOncologyAdverse effectChemistryCholesterolBiochemistryGeneLipoproteins and Cardiovascular HealthRNA and protein synthesis mechanismsRNA Research and Splicing