All-in-one HN@Cu-MOF nanoparticles with enhanced reactive oxygen species generation and GSH depletion for effective tumor treatment
Shu‐Hui Chen, Yu Yan, Yixuan Chen, Kaili Wang, Yawen Zhang, Xinlong Wang, Xurui Li, Jian Wen, Yue Yuan
Abstract
experiments showed an excellent tumor inhibitory effect upon the treatment. Overall, the HN@Cu-MOF nanoparticle-integrated NO gas therapy and CDT with PDT led to a significant enhancement in GSH consumption and a remarkable elevation in ROS production.
Topics & Concepts
Reactive oxygen speciesSensitizationNanoparticleMaterials scienceOxygenGlutathioneApoptosisCancer researchChemical engineeringNanotechnologyChemistryMedicineImmunologyOrganic chemistryBiochemistryEngineeringEnzymeNanoplatforms for cancer theranosticsMetal-Organic Frameworks: Synthesis and ApplicationsLuminescence and Fluorescent Materials