Photoinduced Cascade C–N/C═O Bond Formation from Bromodifluoroalkyl Reagents, Amines, and H<sub>2</sub>O via a Triple-Cleavage Process
Xiaohui Zhuang, Lan Ling, Yingying Wang, Bingqian Li, Bin Sun, Weike Su, Can Jin
Abstract
A green, sustainable, and straightforward method for the synthesis of unsymmetrical oxalamides via photoinduced C–N/C═O bond formation of bromodifluoroacetamide, amine, and H2O through a triple-cleavage process has been developed. In addition, this approach also provides access to the known bioactive compounds, and a feasible reaction mechanism is proposed. Moreover, the advantages of this transformation, including mild reaction conditions, a broad substrate scope, and operational simplicity, make this protocol attractive for further applications.
Topics & Concepts
ChemistryReagentTriple bondBond cleavageCombinatorial chemistryCleavage (geology)CascadeAmine gas treatingSubstrate (aquarium)CatalysisOrganic chemistryDouble bondGeologyGeotechnical engineeringChromatographyFracture (geology)OceanographyEngineeringFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions