Design of a new palladium(<scp>ii</scp>) halide complex as a bio-active material: synthesis, physico-chemical studies, DFT-computations and evaluation of anti-inflammatory, antioxidant and anti-gastric damage activities
Sarra Bougossa, Noureddine Mhadhbi, Ali Ben Ahmed, Mohamed Hamdi, Kais Elghniji, Erwann Jeanneau, Khaled Hamden, Abderrazek Oueslati, Houcine Naı̈li
Abstract
, these compounds inhibit the key enzyme responsible for neutrophil infiltration as myeloperoxidase (MPO) by 38.7%. The compound also alleviates cellular damage induced by free radicals, demonstrated by a notable 48.3% decrease in thiobarbituric acid reactive substance rates (TBARS) compared to untreated rats. Additionally, these compounds bring about a substantial 30.6% reduction in the surface area of ulcers.
Topics & Concepts
HalideAntioxidantPalladiumChemistryCombinatorial chemistryOrganic chemistryCatalysisMetal complexes synthesis and propertiesMagnetism in coordination complexesCrystal structures of chemical compounds