Punicic acid ameliorates obesity-related hyperlipidemia and fatty liver in mice <i>via</i> regulation of intestinal flora and lipopolysaccharide-related signaling pathways
Liping Chen, Yifan Lei, Changxin Lu, Dingyang Liu, Wenyu Ma, Hengqian Lu, Yongzhong Wang
Abstract
, and elevated levels of microbiota-derived short-chain fatty acids (SCFAs). Moreover, the expression of tight junction proteins correlated with intestinal barrier function was notably restored in the colon. The collected results indicate that PSO may be an effective nutraceutical ingredient for attenuating lipid metabolic disorders.
Topics & Concepts
HyperlipidemiaFatty liverGut floraTLR4DysbiosisEndocrinologySteatosisInternal medicineOxidative stressChemistryBiologyPharmacologyBiochemistrySignal transductionMedicineDiabetes mellitusDiseaseLipid metabolism and disordersPomegranate: compositions and health benefitsKruppel-like factors research