An environmentally responsible route to tezacaftor, a drug for treatment of cystic fibrosis prepared in water <i>via</i> ppm Au catalysis as entry to 2-substituted indoles
Nico Fleck, Rohan M. Thomas, Marcel Müller, Stefan Grimme, Bruce H. Lipshutz
Abstract
An environmentally responsible synthesis of tezacaftor, a drug approved in 2018 currently in use for treatment of cystic fibrosis, is described utilizing chemistry in water enabled by the nonionic surfactant TPGS-750-M.
Topics & Concepts
Cystic fibrosisDrugCatalysisEnvironmentally friendlyPharmacologyChemistryPulmonary surfactantNanotechnologyMedicineOrganic chemistryMaterials scienceBiologyBiochemistryInternal medicineEcologyNanomaterials for catalytic reactionsChemistry and Chemical EngineeringChemical Synthesis and Reactions