TMT-labeling Proteomics of Papillary Thyroid Carcinoma Reveal Invasive Biomarkers
Jiaqi Dai, Xiaqing Yu, Yali Han, Li Chai, Yina Liao, Peng Zhong, Ruting Xie, Xuechen Sun, Qingqing Huang, Jian Wang, Zhiqiang Yin, Yun Zhang, Zhongwei Lv, Chengyou Jia
Abstract
Background and Aim: Invasion and metastasis are critical events in papillary thyroid carcinoma (PTC) progression. Protein markers specific to this process may avoid over-treatment and urgently needed. Methods: TMT-labeled mass spectrometry-based proteomics were carried out on PTC and invasive phenotype (iPTC) (3 pairs per group) and cross validate differentially expressed proteins (DEPs) (FC>1.5 and <0.67 and p<0.05) with GEO and TCGA datasets and the correlation genes of DEPs were also analyzed.
Topics & Concepts
Thyroid carcinomaProteomicsPhenotypeMetastasisDownregulation and upregulationMedicineCancer researchInternal medicineGeneBiologyThyroidOncologyCancerGeneticsThyroid Cancer Diagnosis and TreatmentS100 Proteins and Annexins