Withaferin A, a natural thioredoxin reductase 1 (TrxR1) inhibitor, synergistically enhances the antitumor efficacy of sorafenib through ROS-mediated ER stress and DNA damage in hepatocellular carcinoma cells
Xi Chen, Ning Zhu, Yajie Wu, Ye Zhang, Yuxuan Zhang, Kaiwen Jin, Zhiyi Zhou, Guang Chen, Jiabing Wang
Topics & Concepts
ApoptosisUnfolded protein responseWithaferin AChemistryReactive oxygen speciesMTT assayDNA damageIn vivoCancer researchPharmacologyBiologyWithania somniferaBiochemistryMedicinePathologyDNABiotechnologyAlternative medicinePhytochemicals and Medicinal PlantsMelanoma and MAPK PathwaysRedox biology and oxidative stress