Iodine-mediated oxidative triple functionalization of indolines with azoles and diazonium salts
Yifeng Liu, Xiaoting Gu, Xiaoxiang Zhang, Meilan Xu, Zhuan Zhang, Taoyuan Liang
Abstract
We report an innovative synthetic strategy for the generation of polysubstituted indoles from indolines, aryldiazonium salts, and azoles. The methodology encompasses an electrophilic substitution reaction affording C5-indoline intermediates which undergo an iodine-mediated oxidative transformation coupled with C-H functionalization to yield the indole derivatives.
Topics & Concepts
ChemistrySurface modificationIndolineIndole testIodineYield (engineering)ElectrophileCombinatorial chemistryOxidative phosphorylationHalogenationOrganic chemistryCatalysisMaterials scienceBiochemistryMetallurgyPhysical chemistryCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthesis and Catalytic Reactions