Integrins as Therapeutic Targets for SARS-CoV-2
Timothy E. Gressett, Danielle Nader, Juan Pablo Robles, Tione Buranda, Steven W. Kerrigan, Gregory Bix
Abstract
<p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus of the genus Betacoronavirus. Its genome is composed of four structural proteins known as spike (S), envelope (E), membrane (M), and nucleocapsid (N), of which E, M, and N are integrated into the viral envelope. The S glycoprotein, which protrudes from the surface of mature virions as a spike, is essential for virus attachment, fusion, and entry into the host cell.</p>
Topics & Concepts
VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Integrin2019-20 coronavirus outbreakVirusBiologyHost (biology)MicrobiologyCellMedicineGeneticsOutbreakInfectious disease (medical specialty)PathologyDiseaseSARS-CoV-2 and COVID-19 ResearchLipid Membrane Structure and BehaviorBiochemical and Structural Characterization