Epitranscriptome in action: RNA modifications in the DNA damage response
Blerta Xhemalçe, Kyle M. Miller, Natalia Gromak
Abstract
C, and RNA editing. We also discuss stress-induced RNA damage, including RNA alkylation/oxidation, RNA-protein crosslinks, and UV-induced RNA damage. Uncovering molecular mechanisms that underpin the contribution of RNA modifications to DDR and genome stability will have direct application to disease and approaches for therapeutic intervention.
Topics & Concepts
BiologyRNADNA damageAction (physics)DNAComputational biologyGeneticsCell biologyGeneQuantum mechanicsPhysicsRNA modifications and cancerRNA Research and SplicingRNA regulation and disease