Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy
Amin Mahpour, Alan C. Mullen
Abstract
Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the function of lncRNAs in the liver in both health and disease, as well as discuss approaches that could be used to target these non-coding transcripts for therapeutic purposes.
Topics & Concepts
MalignancyDiseaseBiologyHepatocellular carcinomaLiver diseaseFunction (biology)Long non-coding RNALiver fibrosisComputational biologyBioinformaticsFibrosisCancer researchMedicineRNAPathologyGeneticsGeneBiochemistryCancer-related molecular mechanisms researchCholangiocarcinoma and Gallbladder Cancer StudiesRNA modifications and cancer