Predominance of High-Level Tetracycline-Resistant Neisseria gonorrhoeae in Kenya: Implications for Global Implementation of Doxycycline Postexposure Prophylaxis for Prevention of Sexually Transmitted Infections
Olusegun O. Soge, Rodal Issema, Elizabeth A. Bukusi, Jared M. Baeten, Andrew Mujugira, Connie Celum, R. Scott McClelland, Jenell Stewart, for the Partners PrEP Study Team
Abstract
ABSTRACT: Using archived Neisseria gonorrhoeae samples from 2008 to 2012, the prevalence of tet (M) genemediating high-level tetracycline resistance in N. gonorrhoeae was 96% among 50 Kenyan women. Determining the local and national prevalence of gonococcal tetracycline resistance and surveillance of gonococcal antimicrobial resistance can inform the implementation of doxycycline postexposure prophylaxis for STI prevention.
Topics & Concepts
Neisseria gonorrhoeaeDoxycyclineMedicineTetracyclineGonorrheaSexually transmitted diseaseGonococcal infectionAntibiotic resistanceMicrobiologyVirologySyphilisAntibioticsHuman immunodeficiency virus (HIV)BiologySyphilis Diagnosis and TreatmentReproductive tract infections researchHIV/AIDS Research and Interventions