S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis
Qianqian Wang, Jianwei Zheng, June X. Zou, Jianzhen Xu, Fanghai Han, Songtao Xiang, Peiqing Liu, Hong-Wu Chen, Junjian Wang
Topics & Concepts
Degradation (telecommunications)TamoxifenChemistryMethyltransferaseBreast cancerRedoxPharmacologyCancer researchInternal medicineMedicineCancerBiochemistryComputer scienceInorganic chemistryDNAMethylationTelecommunicationsEpigenetics and DNA MethylationHistone Deacetylase Inhibitors ResearchRNA modifications and cancer