Multi-functionalization of β-trifluoromethyl enones enabled 2,3-dihydrofuran synthesis
Ya-Fei Hu, Wei Han, Ye-Kun Chen, Mengtao Ma, Zhi‐Liang Shen, Xue‐Qiang Chu
Abstract
A transition-metal-free multi-functionalization reaction of β-trifluoromethyl enones and azacycles is first developed for the synthesis of valuable amino-2,3-dihydrofuran derivatives.
Topics & Concepts
ChemistrySurface modificationTrifluoromethylCombinatorial chemistryOrganic chemistryPhysical chemistryAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsAsymmetric Synthesis and Catalysis