Sulfane Sulfur Posttranslationally Modifies the Global Regulator AdpA to Influence Actinorhodin Production and Morphological Differentiation of Streptomyces coelicolor
Ting Lu, Xiaohua Wu, Qun Cao, Yongzhen Xia, Luying Xun, Huaiwei Liu
Abstract
, this mechanism may represent a common regulating pattern of all AdpA-controlled biosynthetic pathways. Thus, this finding provides a new strategy for mining and activating valuable biosynthetic gene clusters.
Topics & Concepts
ActinorhodinStreptomyces coelicolorRegulatorCell biologyStreptomycesMicrobiologyChemistryBiologyBiochemistryGeneGeneticsBacteriaMicrobial Natural Products and BiosynthesisSulfur-Based Synthesis TechniquesPesticide and Herbicide Environmental Studies