Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors
Jian Zhang, Yue Dong, Shenghua Gao, Xujie Zhang, Hui Liao, Xiaoyu Shi, Zhijiao Zhang, Tong Zhao, Ruipeng Liang, Danhui Qi, Ting Wu, Jianxin Pang, Xinyong Liu, Peng Zhan
Topics & Concepts
ChemistryIn vivoIC50HyperuricemiaGoutUric acidIn vitroPharmacologyStereochemistryStructure–activity relationshipBiochemistryMedicineBiotechnologyBiologyGout, Hyperuricemia, Uric AcidCase Reports on HematomasEosinophilic Disorders and Syndromes