Sn(<scp>iv</scp>)-porphyrinoids for photodynamic anticancer and antimicrobial chemotherapy
Balaji Babu, John Mack, Tebello Nyokong
Abstract
-diaxial ligation hinders the approach of the Sn(IV) porphyrins, thereby suppressing aggregation effects. In this review, we document the recently reported Sn(IV) porphyrinoids and their photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT) activity properties. In a similar manner to PDT, the photosensitizer is used to kill the bacteria upon irradiation with light during PACT. Often, bacteria develop resistance against conventional chemotherapeutic drugs over time, decreasing their antibacterial properties. However, in the case of PACT, it is difficult to generate resistance against singlet oxygen produced by the photosensitizer.
Topics & Concepts
Photodynamic therapyAntimicrobialAntimicrobial chemotherapyChemotherapyMedicineChemistryPharmacologyCombinatorial chemistryInternal medicineOrganic chemistryPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranostics