Clearance of Immunodeficiency-associated Vaccine-derived Poliovirus Infection With Pocapavir
Julie Copelyn, Jeffrey R. Hincks, Jo M. Wilmshurst, Wonita Petersen, Wayne Howard, Sabelle Jallow, Shelina Moonsamy, Lerato Seakamela, Melinda Suchard, Marc S. Collett, Brian Eley
Abstract
Pocapavir exhibits antiviral activity against both polio and nonpolio enteroviruses. There is limited experience of the use of this investigational drug in young children with enteroviral infection. We describe the successful clearance of prolonged immunodeficiency-associated vaccine-derived type 3 poliovirus infection by pocapavir in an infant with underlying X-linked agammaglobulinemia.
Topics & Concepts
PoliovirusVirologyPoliomyelitisMedicineImmunodeficiencyHuman immunodeficiency virus (HIV)ImmunologyPolio vaccineVirusImmune systemViral Infections and Immunology ResearchImmunodeficiency and Autoimmune DisordersViral gastroenteritis research and epidemiology