KPNA2 Silencing, Regulated by E3 Ubiquitin Ligase FBXW7, Alleviates Endothelial Dysfunction and Inflammation Through Inhibiting the Nuclear Translocation of p65 and IRF3: A Possible Therapeutic Approach for Atherosclerosis
Zeyu Xing, Yanhua Zhen, Jie Chen, Mingyang Du, Dongdong Li, Ruyin Liu, Jiahe Zheng
Topics & Concepts
Ubiquitin ligaseIRF3Downregulation and upregulationGene silencingUbiquitinBiologyInflammationGene knockdownCell biologyProinflammatory cytokineTranscription factorCancer researchMolecular biologyImmunologyCell cultureBiochemistryGeneGeneticsNuclear Structure and FunctionRNA Research and SplicingRNA modifications and cancer