IRF5 guides monocytes toward an inflammatory CD11c <sup>+</sup> macrophage phenotype and promotes intestinal inflammation
Alastair Corbin, Maria Gomez-Vazquez, Dorothée L. Berthold, Moustafa Attar, Isabelle C. Arnold, Fiona Powrie, Stephen N. Sansom, Irina A. Udalova
Abstract
macrophages and controls the production of antimicrobial and inflammatory mediators by these cells. Thus, we identify IRF5 as a key transcriptional regulator of the colonic MNP system during intestinal inflammation.
Topics & Concepts
InflammationIRF5CD11cMacrophagePhenotypeImmunologyBiologyTranscription factorInnate immune systemInterferon regulatory factorsGeneImmune systemGeneticsIn vitroIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionHelicobacter pylori-related gastroenterology studies