Emergence of the Novel Aminoglycoside Acetyltransferase Variant <i>aac(6′)-Ib-D179Y</i> and Acquisition of Colistin Heteroresistance in Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Due to a Disrupting Mutation in the DNA Repair Enzyme MutS
Toyotaka Sato, Takayuki Wada, Suguru Nishijima, Yukari Fukushima, Chie Nakajima, Yasuhiko Suzuki, Satoshi Takahashi, Shin‐ichi Yokota
Abstract
The emergence of multidrug resistance in pathogens such as Klebsiella pneumoniae is of great clinical concern. Antimicrobial resistance sometimes arises during the course of an infection.
Topics & Concepts
AmikacinKlebsiella pneumoniaeColistinMicrobiologyCarbapenemBiologyNonsense mutationAntimicrobialMutationAntibioticsGeneGeneticsEscherichia coliMissense mutationAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyCancer therapeutics and mechanisms