Silencing of m<sup>6</sup>A methyltransferase KIAA1429 suppresses the progression of non-small cell lung cancer by promoting the p53 signaling pathway and ferroptosis.
Yuanzhou Wu, Hui Li, Yang Huang, Qunqing Chen
Abstract
effects were weakened by pifithrin-μ, a p53 inhibitor. Therefore, given its effects on ferroptosis and the p53 signaling pathway, targeting KIAA1429 could be an effective strategy for treating NSCLC.
Topics & Concepts
Gene silencingCancer researchSmall interfering RNATranscriptomeMethyltransferaseLung cancerDownregulation and upregulationBiologySignal transductionIn vitroIn vivoCell biologyGene expressionCell cultureTransfectionMedicineGenePathologyMethylationGeneticsRNA modifications and cancerCancer-related gene regulationEpigenetics and DNA Methylation