Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone
Mert Icyuz, Michael Fitch, Fang Zhang, Anil K. Challa, Liou Y. Sun
Abstract
mice are exhibiting the consistent and unique physiological and metabolic characteristics, which might mediate the longevity effects of growth hormone deficiency in mice.
Topics & Concepts
Internal medicineEndocrinologyHormoneBiologyRespiratory exchange ratioWild typeGrowth hormone–releasing hormoneGrowth hormone deficiencyGrowth hormoneGeneGeneticsMedicineMutantHeart rateBlood pressureGenetics, Aging, and Longevity in Model OrganismsPluripotent Stem Cells ResearchBirth, Development, and Health