Chemiluminescence resonance energy transfer–based nanoparticles for quantum yield–enhanced cancer phototheranostics
Jueun Jeon, Dong Gil You, Wooram Um, Jeongjin Lee, Chan Ho Kim, Sol Shin, Seunglee Kwon, Jae Hyung Park
Abstract
generation, CRET-NPs were capable of generating a strong and long-lasting photoacoustic signal in the tumor tissue via thermal expansion-induced vaporization. In addition, the CRET phenomenon of the NPs enhanced ROS quantum yield of photosensitizer through both electron transfer for an oxygen-independent type I photochemical reaction and self-illumination for an oxygen-dependent type II photochemical reaction. Consequently, owing to their high ROS quantum yield, CRET-NPs effectively inhibited tumor growth with complete tumor growth inhibition in 60% of cases, even with a single treatment.
Topics & Concepts
ChemiluminescenceQuantum yieldEnergy transferNanoparticleYield (engineering)Resonance (particle physics)CancerMaterials scienceFörster resonance energy transferCancer detectionQuantumNanotechnologyChemistryPhysicsAtomic physicsMedicineChemical physicsFluorescenceOpticsChromatographyQuantum mechanicsComposite materialInternal medicineNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingPhotodynamic Therapy Research Studies