Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions
Ben J. Marais, Elaine Cheong, Shelanah Fernando, Santhosh Daniel, Matthew Watts, Lucinda J. Berglund, Simone Barry, George Kotsiou, Alex P. Headley, Richard Stapledon
Abstract
We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.
Topics & Concepts
InfliximabMedicineParadoxical reactionTuberculous meningitisMeningitisTuberculosisIntensive care medicineSurgeryInternal medicineTumor necrosis factor alphaPathologyInfectious Diseases and TuberculosisTuberculosis Research and EpidemiologyPneumocystis jirovecii pneumonia detection and treatment